human DDIT4 shRNA silencing Adenovirus

Name 
Ad-h-DDIT4-shRNA
Cat No 
shADV-206707
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DDIT4.

shADV-206707
Ad-h-DDIT4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DDIT4 (DNA damage inducible transcript 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Dig2; DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1; REDD1; REDD-1
Description (eCommerce)
REDD1 (regulated in development and DNA damage response 1) is a direct transcriptional target of HIF. It plays a role in the TSC/mTOR pathway as a regulator upstream of the TSC1/2 complex. In response to both hypoxia and energy stress, REDD1 inhibits mTOR activity in a TSC-dependent manner. Alternative names for REDD1 include DDIT4, DNA-damage-inducible transcript 4 protein, and RTP801.
Gene ID
54541
Gene Name (eCommerce)
DNA damage inducible transcript 4
Gene Name (Vector)
DNA damage inducible transcript 4
Gene Symbol
DDIT4
HGNC ID
HGNC:24944
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
699
ORF Size (bp)
699 bp
Protein Name (eCommerce)
DNA damage-inducible transcript 4 protein
RefSeq ID
NM_019058
RefSeq Synonyms
NM_019058, BC015236, BC007714, BC000708,
Research Areas
Apoptosis,Brain Development,Cancer,Host-Virus Interactions,Hypoxia,MicroRNAs in Cancer,Mitochondrion,mTOR Signaling,Neurobiology,Neurodevelopment,NGF Signaling,PI3K/Akt Signaling,Response to Virus,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
REDD1 (regulated in development and DNA damage response 1) is a direct transcriptional target of HIF. It plays a role in the TSC/mTOR pathway as a regulator upstream of the TSC1/2 complex. In response to both hypoxia and energy stress, REDD1 inhibits mTOR activity in a TSC-dependent manner. Alternative names for REDD1 include DDIT4, DNA-damage-inducible transcript 4 protein, and RTP801.
UniGene ID
Hs.523012
UniProt ID (eCommerce)
Q9NX09

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.