human DAB2IP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DAB2IP.
shADV-206567
Ad-h-DAB2IP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DAB2IP (DAB2 interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AF9Q34; AIP1; AIP-1; ASK1-interacting protein 1; ASK-interacting protein 1; DAB2 interaction protein; DAB2-interacting protein; DIP1/2; disabled homolog 2-interacting protein; DOC-2/DAB2 interactive protein; DOC-2/DAB-2 interactive protein; nGAP-like protein
Description (eCommerce)
DAB2-interacting protein (DAB2IP) functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5, it disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. DAB2IP also Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. DAB2IP may act as a tumor suppressor gene [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5VWQ8].
Description (Vector)
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 (PubMed 15386433)).(supplied by OMIM, May 2010)
Gene ID
153090
Gene Name (eCommerce)
DAB2 interacting protein
Gene Name (Vector)
DAB2 interacting protein
Gene Symbol
DAB2IP
HGNC ID
HGNC:17294
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3111
ORF Size (bp)
3111 bp
Protein Name (eCommerce)
Disabled homolog 2-interacting protein
RefSeq ID
NM_032552
RefSeq Synonyms
NM_138709, NM_032552, BC146762,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cell Cycle,Immunology,Innate Immunity,JNK Signaling,NF-kB Signaling,Protein Folding,Signal Transduction,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,signal_transduction
Species
human
Target Sentence
DAB2-interacting protein (DAB2IP) functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5, it disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. DAB2IP also Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. DAB2IP may act as a tumor suppressor gene [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5VWQ8].
UniGene ID
Hs.522378
UniProt ID (eCommerce)
Q5VWQ8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.