human KLKB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KLKB1.
shADV-206523
Ad-h-KLKB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KLKB1 (kallikrein B1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KLK3; PKK; PKKD; PPK
Description (Vector)
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Gene ID
3818
Gene Name (Vector)
kallikrein B1
Gene Symbol
KLKB1
HGNC ID
HGNC:6371
ORF Size (aa)
1917
ORF Size (bp)
1917 bp
RefSeq ID
NM_000892
RefSeq Synonyms
NM_001318396, NM_001318394, NM_000892, BC117351, BC117349,
Species
human
UniGene ID
Hs.237642
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.