human CYP17A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CYP17A1.
shADV-206446
Ad-h-CYP17A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CPT7; CYP17; P450C17; S17AH
Description (Vector)
CYP17A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Gene ID
1586
Gene Name (Vector)
cytochrome P450 family 17 subfamily A member 1
Gene Symbol
CYP17A1
HGNC ID
HGNC:2593
ORF Size (aa)
1527
ORF Size (bp)
1527 bp
RefSeq ID
NM_000102
RefSeq Synonyms
NM_000102, BC063388, BC062997,
Species
human
UniGene ID
Hs.438016
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.