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human CYFIP1 shRNA silencing Adenovirus

Name 
Ad-h-CYFIP1-shRNA
Cat No 
shADV-206433
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CYFIP1.

shADV-206433
Ad-h-CYFIP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CYFIP1 (cytoplasmic FMR1 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; P140SRA-1; selective hybridizing clone; SHYC; specifically Rac1-associated protein 1; SRA1; SRA-1
Description (eCommerce)
Cytoplasmic FMR1-interacting protein 1 is a component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. CYFIP1 promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. CYFIP1 is involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. CYFIP1 may act as an invasion suppressor in cancers [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q7L576].
Gene ID
23191
Gene Name (eCommerce)
cytoplasmic FMR1 interacting protein 1
Gene Name (Vector)
cytoplasmic FMR1 interacting protein 1
Gene Symbol
CYFIP1
HGNC ID
HGNC:13759
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3762
ORF Size (bp)
3762 bp
Protein Name (eCommerce)
Cytoplasmic FMR1-interacting protein 1
RefSeq ID
NM_014608
RefSeq Synonyms
NM_014608, NM_001324126, NM_001324125, NM_001324124, NM_001324123, NM_001324122, NM_001324120, NM_001324119, NM_001287810, NM_001033028, BC005097,
Research Areas
BDNF Signaling,Cytoskeleton,Immunology,mRNA Binding,Neurobiology,Neurodevelopment,Neurogenesis,RNA Transport,Synapse,T-cell Receptor Signaling,Translational Control
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Cytoplasmic FMR1-interacting protein 1 is a component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. CYFIP1 promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. CYFIP1 is involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. CYFIP1 may act as an invasion suppressor in cancers [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q7L576].
UniGene ID
Hs.26704
UniProt ID (eCommerce)
Q7L576

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.