human CYBB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CYBB.
shADV-206408
Ad-h-CYBB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CYBB (cytochrome b-245 beta chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
Description (Vector)
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Gene ID
1536
Gene Name (Vector)
cytochrome b-245 beta chain
Gene Symbol
CYBB
HGNC ID
HGNC:2578
ORF Size (aa)
1713
ORF Size (bp)
1713 bp
RefSeq ID
NM_000397
RefSeq Synonyms
NM_000397, BC032720,
Species
human
UniGene ID
Hs.292356
Recently Viewed Products
Ad-CMV-Luc
Cat No: 1000
Ad-CMV-Akt1 (Myr)
Cat No: 1020
Ad-CMV-Akt1 (dn)
Cat No: 1021
Ad-CMV-Akt1 (wt)
Cat No: 1022
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.