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human CUL9 shRNA silencing Adenovirus

Name 
Ad-h-CUL9-shRNA
Cat No 
shADV-206305
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CUL9.

shADV-206305
Ad-h-CUL9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CUL9 (cullin 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CUL-9; cullin-9; H7AP1; p53-associated parkin-like cytoplasmic protein; PARC; parkin-like cytoplasmic p53 binding protein; UbcH7-associated protein 1
Description (eCommerce)
PARC is a member of the cullin family of proteins that act as scaffolds to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. PARC is highly homologous to and can form heterodimers with CUL7 (cullin 7). PARC/H7 interacts with p53 and was initially thought to have a role in the sequestration of p53 to the cytoplasm. Recent studies demonstrate that PARC may not influence p53 function or localization, but rather p53 may serve to regulate PARC/H7-AP1 function.
Gene ID
23113
Gene Name (eCommerce)
cullin 9
Gene Name (Vector)
cullin 9
Gene Symbol
CUL9
HGNC ID
HGNC:15982
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7551
ORF Size (bp)
7551 bp
Protein Name (eCommerce)
Cullin-9
RefSeq ID
NM_015089
RefSeq Synonyms
NM_015089, BC148597,
Research Areas
Cell Cycle,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
PARC is a member of the cullin family of proteins that act as scaffolds to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. PARC is highly homologous to and can form heterodimers with CUL7 (cullin 7). PARC/H7 interacts with p53 and was initially thought to have a role in the sequestration of p53 to the cytoplasm. Recent studies demonstrate that PARC may not influence p53 function or localization, but rather p53 may serve to regulate PARC/H7-AP1 function.
UniGene ID
Hs.485434
UniProt ID (eCommerce)
Q8IWT3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.