human SLC12A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SLC12A1.
shADV-206289
Ad-h-SLC12A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SLC12A1 (solute carrier family 12 member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BSC1; NKCC2
Description (Vector)
SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Gene ID
6557
Gene Name (Vector)
solute carrier family 12 member 1
Gene Symbol
SLC12A1
HGNC ID
HGNC:10910
ORF Size (aa)
3300
ORF Size (bp)
3300 bp
RefSeq ID
NM_000338
RefSeq Synonyms
NM_001184832, NM_000338, BC156819, BC148651, BC040138,
Species
human
UniGene ID
Hs.123116
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.