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human CTDP1 shRNA silencing Adenovirus

Name 
Ad-h-CTDP1-shRNA
Cat No 
shADV-206225
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CTDP1.

shADV-206225
Ad-h-CTDP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CTDP1 (CTD phosphatase subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CCFDN; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; CTD of POLR2A, phosphatase of, subunit 1; FCP1; RNA polymerase II subunit A C-terminal domain phosphatase; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase; TFIIF-associating CTD phosphatase 1; transcription factor IIF-associating CTD phosphatase 1
Description (eCommerce)
CTDP1/FCP1 is a phosphatase that is responsible for the dephosphorylation of RNA polymerase II (RNA Pol II) C-terminal domain (CTD) and is a critical regulator of RNA Pol II function in the steps of transcription.
Description (Vector)
CTDP1 encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
9150
Gene Name (eCommerce)
CTD phosphatase subunit 1
Gene Name (Vector)
CTD phosphatase subunit 1
Gene Symbol
CTDP1
HGNC ID
HGNC:2498
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2604
ORF Size (bp)
2604 bp
Protein Name (eCommerce)
RNA polymerase II subunit A C-terminal domain phosphatase
RefSeq ID
NM_004715
RefSeq Synonyms
NM_048368, NM_004715, NM_001318511, NM_001202504, BC063447,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Gene Expression,Host-Virus Interactions,Kinase/Phosphatase,Phosphatase,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
CTDP1/FCP1 is a phosphatase that is responsible for the dephosphorylation of RNA polymerase II (RNA Pol II) C-terminal domain (CTD) and is a critical regulator of RNA Pol II function in the steps of transcription.
UniGene ID
Hs.465490
UniProt ID (eCommerce)
Q9Y5B0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.