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human CSPG4 shRNA silencing Adenovirus

Name 
Ad-h-CSPG4-shRNA
Cat No 
shADV-206156
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CSPG4.

shADV-206156
Ad-h-CSPG4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CSPG4 (chondroitin sulfate proteoglycan 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan NG2; HMW-MAA; MCSP; MCSPG; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; MEL-CSPG; MSK16; NG2
Description (eCommerce)
Melanoma chondroitin sulfate proteoglycan (MCSP) is a cell-surface antigen expressed early in melanoma progression. It has been found to be involved in the spreading, invasion, and migration of human melanoma. MCSP influences melanoma behavior via the activation of the Cdc42 GTPase and phosphorylation of p130Cas. MCSP also activates signaling cascades involving FAK and ERK1/ERK2. In addition to its expression in melanoma cells, MCSP is also found in breast carcinomas, gliomas, neuroblastomas, and acute leukemias. MCSP is being considered as a target antigen for cancer immunotherapy.
Description (Vector)
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
Gene ID
1464
Gene Name (eCommerce)
chondroitin sulfate proteoglycan 4
Gene Name (Vector)
chondroitin sulfate proteoglycan 4
Gene Symbol
CSPG4
HGNC ID
HGNC:2466
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6966
ORF Size (bp)
6966 bp
Protein Name (eCommerce)
Chondroitin sulfate proteoglycan 4
RefSeq ID
NM_001897
RefSeq Synonyms
NM_001897, BC172576, BC172270,
Research Areas
Angiogenesis,Golgi Apparatus,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Melanoma chondroitin sulfate proteoglycan (MCSP) is a cell-surface antigen expressed early in melanoma progression. It has been found to be involved in the spreading, invasion, and migration of human melanoma. MCSP influences melanoma behavior via the activation of the Cdc42 GTPase and phosphorylation of p130Cas. MCSP also activates signaling cascades involving FAK and ERK1/ERK2. In addition to its expression in melanoma cells, MCSP is also found in breast carcinomas, gliomas, neuroblastomas, and acute leukemias. MCSP is being considered as a target antigen for cancer immunotherapy.
UniGene ID
Hs.513044
UniProt ID (eCommerce)
Q6UVK1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.