human CREBL2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CREBL2.
shADV-205982
Ad-h-CREBL2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CREBL2 (cAMP responsive element binding protein like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
Gene ID
1389
Gene Name (Vector)
cAMP responsive element binding protein like 2
Gene Symbol
CREBL2
HGNC ID
HGNC:2350
ORF Size (aa)
363
ORF Size (bp)
363 bp
RefSeq ID
NM_001310
RefSeq Synonyms
NM_001310, BC112157, BC106052, BC104873,
Species
human
UniGene ID
Hs.591156
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.