Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human CRABP2 shRNA silencing Adenovirus

Name 
Ad-h-CRABP2-shRNA
Cat No 
shADV-205956
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CRABP2.

shADV-205956
Ad-h-CRABP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CRABP2 (cellular retinoic acid binding protein 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II; CRABP-II; RBP6
Description (eCommerce)
Cellular retinoic acid binding protein 2 (CRABP2) is a coactivator present in the retinoic acid (RA)-dependent nuclear complex. CRABP2 has been shown to mediate retinoic acid activity in skin to influence skin cell growth and differentiation. It has also been shown to mediate the growth suppressive effects of retinoic acid in breast cancer. CRABP2’s role in cell differentiation may be linked to control of the cell-cycle since it has been identified as an interacting partner of cyclin D3 in CRABPII and RAR ternary complex.
Description (Vector)
CRABP2 encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene ID
1382
Gene Name (eCommerce)
cellular retinoic acid binding protein 2
Gene Name (Vector)
cellular retinoic acid binding protein 2
Gene Symbol
CRABP2
HGNC ID
HGNC:2339
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
417
Protein Name (eCommerce)
Cellular retinoic acid-binding protein 2
RefSeq ID
NM_001878
RefSeq Synonyms
NM_001878, NM_001199723, BC001109,
Research Areas
Signal Transduction,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Cellular retinoic acid binding protein 2 (CRABP2) is a coactivator present in the retinoic acid (RA)-dependent nuclear complex. CRABP2 has been shown to mediate retinoic acid activity in skin to influence skin cell growth and differentiation. It has also been shown to mediate the growth suppressive effects of retinoic acid in breast cancer. CRABP2’s role in cell differentiation may be linked to control of the cell-cycle since it has been identified as an interacting partner of cyclin D3 in CRABPII and RAR ternary complex.
UniGene ID
Hs.405662
UniProt ID (eCommerce)
P29373

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.