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human CORO7 shRNA silencing Adenovirus

Name 
Ad-h-CORO7-shRNA
Cat No 
shADV-205805
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CORO7.

shADV-205805
Ad-h-CORO7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CORO7 (coronin 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
0610011B16Rik; 70 kDa WD repeat tumor rejection antigen homolog; coronin-7; CRN7; POD1
Description (eCommerce)
CORO7 is a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. CORO7 has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology [taken from NCBI Entrez Gene (Gene ID: 79585)].
Description (Vector)
Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 (PubMed 15327992) (PubMed 16905771)).(supplied by OMIM, Mar 2008)
Gene ID
79585
Gene Name (eCommerce)
coronin 7
Gene Name (Vector)
coronin 7
Gene Symbol
CORO7
HGNC ID
HGNC:26161
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2778
ORF Size (bp)
2778 bp
Protein Name (eCommerce)
Coronin-7
RefSeq ID
NM_024535
RefSeq Synonyms
NM_024535, NM_001201473, NM_001201472, BC117291, BC117289,
Research Areas
Cytoskeleton,Golgi Apparatus
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
CORO7 is a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. CORO7 has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology [taken from NCBI Entrez Gene (Gene ID: 79585)].
UniGene ID
Hs.437957
UniProt ID (eCommerce)
P57737

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.