human COL1A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human COL1A1.
shADV-205689
Ad-h-COL1A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human COL1A1 (collagen type I alpha 1 chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EDSC; OI1; OI2; OI3; OI4
Description (Vector)
COL1A1 encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (provided by R. Dalgleish, Feb 2008)
Gene ID
1277
Gene Name (Vector)
collagen type I alpha 1 chain
Gene Symbol
COL1A1
HGNC ID
HGNC:2197
ORF Size (aa)
4395
ORF Size (bp)
4395 bp
RefSeq ID
NM_000088
RefSeq Synonyms
NM_000088, BC036531,
Species
human
UniGene ID
Hs.681002
Recently Viewed Products
Ad-m-PSMA8-shRNA
Cat No: shADV-269629
Ad-RPL21
Cat No: 1523
Ad-h-RHEB-shRNA
Cat No: shADV-208542
AAV-r-ARAF-shRNA
Cat No: shAAV-290030
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.