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human CNTNAP2 shRNA silencing Adenovirus

Name 
Ad-h-CNTNAP2-shRNA
Cat No 
shADV-205651
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CNTNAP2.

shADV-205651
Ad-h-CNTNAP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CNTNAP2 (contactin associated protein-like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AUTS15; CASPR2; CDFE; NRXN4; PTHSL1
Description (Vector)
CNTNAP2 encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. CNTNAP2 encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. CNTNAP2 has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
Gene ID
26047
Gene Name (Vector)
contactin associated protein-like 2
Gene Symbol
CNTNAP2
HGNC ID
HGNC:13830
ORF Size (aa)
3996
ORF Size (bp)
3996 bp
RefSeq ID
NM_014141
RefSeq Synonyms
NM_014141, BC113373, BC093780,
Species
human
UniGene ID
Hs.655684

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.