human CLN8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CLN8.
shADV-205488
Ad-h-CLN8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CLN8 (ceroid-lipofuscinosis, neuronal 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C8orf61; EPMR
Description (Vector)
CLN8 encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
Gene ID
2055
Gene Name (Vector)
ceroid-lipofuscinosis, neuronal 8
Gene Symbol
CLN8
HGNC ID
HGNC:2079
ORF Size (aa)
933
ORF Size (bp)
933 bp
RefSeq ID
NM_018941
RefSeq Synonyms
NM_018941, BC136825, BC007725,
Species
human
UniGene ID
Hs.127675
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.