human CHRNA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CHRNA2.
shADV-205204
Ad-h-CHRNA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CHRNA2 (cholinergic receptor, nicotinic, alpha 2 (neuronal)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP13A; CGI-152; DKFZp761L1623; FLJ31858; FLJ41786; FLJ43873; FLJ90317; KIAA1825;
Description (Vector)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
Gene ID
1135
Gene Name (Vector)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
Gene Symbol
CHRNA2
HGNC ID
HGNC:1956
ORF Size (aa)
1590
ORF Size (bp)
1590 bp
RefSeq ID
NM_000742
RefSeq Synonyms
NM_001282455, NM_000742, BC153866,
Species
human
UniGene ID
Hs.57718
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.