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human CHD7 shRNA silencing Adenovirus

Name 
Ad-h-CHD7-shRNA
Cat No 
shADV-205118
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CHD7.

shADV-205118
Ad-h-CHD7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CHD7 (chromodomain helicase DNA binding protein 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATP-dependent helicase CHD7; CHARGE association; CHD-7; chromodomain helicase DNA binding protein 7 isoform CRA_e; chromodomain-helicase-DNA-binding protein 7; CRG; HH5; IS3; KAL5
Description (eCommerce)
CHD7 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD7 is implicated to play a role in development. Mutations in CHD7 are associated with CHARGE syndrome, a multi-symptom syndrome characterized by congenital anomalies and malformations of the heart, inner ear, retina, and palate.
Description (Vector)
CHD7 encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome.
Gene ID
55636
Gene Name (eCommerce)
chromodomain helicase DNA binding protein 7
Gene Name (Vector)
chromodomain helicase DNA binding protein 7
Gene Symbol
CHD7
HGNC ID
HGNC:20626
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
8994
ORF Size (bp)
8994 bp
Protein Name (eCommerce)
Chromodomain-helicase-DNA-binding protein 7
RefSeq ID
NM_017780
RefSeq Synonyms
NM_017780, NM_001316690, BC172443,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Chromatin Remodeling,Helicase Activity,Immunology,Neurobiology,Neurodevelopment,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
signal_transduction,cardiovascular,cell_biology,transcription_translation,cell_biology,immunology,neurobiology,developmental_biology,genetics,transcription_translation,signal_transduction,developmental_biology
Species
human
Target Sentence
CHD7 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD7 is implicated to play a role in development. Mutations in CHD7 are associated with CHARGE syndrome, a multi-symptom syndrome characterized by congenital anomalies and malformations of the heart, inner ear, retina, and palate.
UniGene ID
Hs.20395
UniProt ID (eCommerce)
Q9P2D1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.