human CHAF1B shRNA silencing Adenovirus

Name 
Ad-h-CHAF1B-shRNA
Cat No 
shADV-205096
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CHAF1B.

shADV-205096
Ad-h-CHAF1B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CHAF1B (chromatin assembly factor 1 subunit B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CAF1; CAF-1; CAF-1 subunit B; CAF1A; CAF1P60; CAF-I 60 kDa subunit; CAF-I p60; CAF-IP60; chromatin assembly factor 1 subunit B; chromatin assembly factor I p60 subunit; human chromatin assembly factor-I p60 subunit; M-phase phosphoprotein 7; MPHOSPH7; MPP7
Description (eCommerce)
The chromatin assembly factor 1 (CAF-1) is a trimeric histone chaperone that mediates the assembly of newly replicated DNA into chromatin. CAF-1 p60 is the 60 kDa subunit of the CAF-1 trimeric factor. CAF-1 p60, along with p150 and p48, has been demonstrated to be required for proper nucleosome assembly and proliferating cell viability.
Description (Vector)
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.
Gene ID
8208
Gene Name (eCommerce)
chromatin assembly factor 1 subunit B
Gene Name (Vector)
chromatin assembly factor 1 subunit B
Gene Symbol
CHAF1B
HGNC ID
HGNC:1911
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1680
ORF Size (bp)
1680 bp
Protein Name (eCommerce)
Chromatin assembly factor 1 subunit B
RefSeq ID
NM_005441
RefSeq Synonyms
NM_005441, BC021218,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,DNA Replication,Histone Modification,Protein Folding,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
The chromatin assembly factor 1 (CAF-1) is a trimeric histone chaperone that mediates the assembly of newly replicated DNA into chromatin. CAF-1 p60 is the 60 kDa subunit of the CAF-1 trimeric factor. CAF-1 p60, along with p150 and p48, has been demonstrated to be required for proper nucleosome assembly and proliferating cell viability.
UniGene ID
Hs.75238
UniProt ID (eCommerce)
Q13112

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.