human CDKN1B shRNA silencing Adenovirus

Name
Ad-h-CDKN1B-shRNA

Cat No
shADV-204878

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CDKN1B.

shADV-204878

Ad-h-CDKN1B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDKN1B (cyclin dependent kinase inhibitor 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CDKN4; KIP1; MEN1B; MEN4; P27KIP1

Description (Vector)

CDKN1B encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Gene ID

1027

Gene Name (Vector)

cyclin dependent kinase inhibitor 1B

Gene Symbol

CDKN1B

HGNC ID

HGNC:1785

ORF Size (aa)

597

ORF Size (bp)

597 bp

RefSeq ID

NM_004064

RefSeq Synonyms

NM_004064, BC001971,

Species

human

UniGene ID

Hs.238990

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.