human CDKL5 shRNA silencing Adenovirus

Name 
Ad-h-CDKL5-shRNA
Cat No 
shADV-204877
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CDKL5.

shADV-204877
Ad-h-CDKL5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDKL5 (cyclin dependent kinase like 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CFAP247; cyclin dependent kinase 5 transcript; cyclin-dependent kinase-like 5; EIEE2; ISSX; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
Description (eCommerce)
Cyclin-dependent kinase-like 5 (CDKL5) is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in the CDKL5 gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT) [taken from NCBI Entrez Gene (Gene ID: 6792)].
Description (Vector)
CDKL5 is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.
Gene ID
6792
Gene Name (eCommerce)
cyclin dependent kinase like 5
Gene Name (Vector)
cyclin dependent kinase like 5
Gene Symbol
CDKL5
HGNC ID
HGNC:11411
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3090
ORF Size (bp)
3090 bp
Protein Name (eCommerce)
Cyclin-dependent kinase-like 5
RefSeq ID
NM_003159
RefSeq Synonyms
NM_003159, NM_001323289, NM_001037343, BC152846,
Research Areas
BDNF Signaling,Epilepsy,Kinase/Phosphatase,Neurobiology,Neurodevelopment,RNA Processing
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Cyclin-dependent kinase-like 5 (CDKL5) is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in the CDKL5 gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT) [taken from NCBI Entrez Gene (Gene ID: 6792)].
UniGene ID
Hs.659851
UniProt ID (eCommerce)
O76039

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.