human CDK2AP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CDK2AP1.
shADV-204840
Ad-h-CDK2AP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
doc-1; DOC1; DORC1; p12DOC-1; ST19
Description (Vector)
CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
8099
Gene Name (Vector)
cyclin dependent kinase 2 associated protein 1
Gene Symbol
CDK2AP1
HGNC ID
HGNC:14002
ORF Size (aa)
348
RefSeq ID
NM_004642
RefSeq Synonyms
NM_004642, NM_001270434, NM_001270433, BC034717,
Species
human
UniGene ID
Hs.433201
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.