human CD8A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD8A.
shADV-204694
Ad-h-CD8A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD8A (CD8a molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD8a; CD8; CD8 antigen, alpha polypeptide (p32); Leu2; Leu2 T-lymphocyte antigen; OKT8 T-cell antigen; p32; T cell co-receptor; T8 T-cell antigen; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2
Description (eCommerce)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].
Description (Vector)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
925
Gene Name (eCommerce)
CD8 subunit alpha
Gene Name (Vector)
CD8a molecule
Gene Symbol
CD8A
HGNC ID
HGNC:1706
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
708
Protein Name (eCommerce)
T-cell surface glycoprotein CD8 alpha chain
RefSeq ID
NM_001768
RefSeq Synonyms
NM_171827, NM_001768, NM_001145873, BC025715,
Research Areas
Antigen Processing and Presentation,Host-Virus Interactions,Immunology,Interleukin Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology,infectious_disease,immunology,signal_transduction
Species
human
Target Sentence
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].
UniGene ID
Hs.85258
UniProt ID (eCommerce)
P01732
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.