human CD276 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD276.
shADV-204622
Ad-h-CD276-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD276 (CD276 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4Ig-B7-H3; B7 homolog 3; B7H3; B7-H3; B7RP-2; CD antigen CD276; CD276 antigen; costimulatory molecule
Description (eCommerce)
CD276 may participate in the regulation of T-cell-mediated immune response. CD276 may play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. It may also be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces and could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5ZPR3].
Description (Vector)
CD276 belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
80381
Gene Name (eCommerce)
CD276 molecule
Gene Name (Vector)
CD276 molecule
Gene Symbol
CD276
HGNC ID
HGNC:19137
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
CD276 antigen
RefSeq ID
NM_001024736
RefSeq Synonyms
NM_025240, NM_001329629, NM_001329628, NM_001024736, BC062581,
Research Areas
Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
CD276 may participate in the regulation of T-cell-mediated immune response. CD276 may play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. It may also be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces and could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5ZPR3].
UniGene ID
Hs.77873
UniProt ID (eCommerce)
Q5ZPR3
Recently Viewed Products
Ad-r-SEC22A-shRNA
Cat No: shADV-291582
Ad-r-PSMA3-shRNA
Cat No: shADV-291642
Ad-h-KRT18-shRNA
Cat No: shADV-213382
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.