human CCNA1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CCNA1.
shADV-204472
Ad-h-CCNA1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CCNA1 (cyclin A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CT146
Description (Vector)
CCNA1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
8900
Gene Name (Vector)
cyclin A1
Gene Symbol
CCNA1
HGNC ID
HGNC:1577
ORF Size (aa)
1395
ORF Size (bp)
1395 bp
RefSeq ID
NM_003914
RefSeq Synonyms
NM_003914, NM_001111047, NM_001111046, NM_001111045, BC036346,
Species
human
UniGene ID
Hs.417050
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.