human CCDC94 shRNA silencing Adenovirus

Name 
Ad-h-CCDC94-shRNA
Cat No 
shADV-204398
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CCDC94.

shADV-204398
Ad-h-CCDC94-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CCDC94 (coiled-coil domain containing 94). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CCDC94; coiled-coil domain containing 94; coiled-coil domain-containing protein 94; YJU2 splicing factor homolog
Description (eCommerce)
CCDC94 is part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. CCDC94 also plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. CCDC94 may protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BW85].
Gene ID
55702
Gene Name (eCommerce)
YJU2 splicing factor homolog
Gene Name (Vector)
coiled-coil domain containing 94
Gene Symbol
CCDC94
HGNC ID
HGNC:25518
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
972
ORF Size (bp)
972 bp
Protein Name (eCommerce)
Coiled-coil domain-containing protein 94
RefSeq ID
NM_018074
RefSeq Synonyms
NM_018074, BC019096, BC000561,
Research Areas
P53 Signaling,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
CCDC94 is part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. CCDC94 also plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. CCDC94 may protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BW85].
UniGene ID
Hs.21811
UniProt ID (eCommerce)
Q9BW85

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.