human CBR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CBR1.
shADV-204175
Ad-h-CBR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CBR1 (carbonyl reductase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase NADP(+); carbonyl reductase (NADPH) 1; carbonyl reductase NADPH 1; CBR; epididymis secretory sperm binding protein; hCBR1; NADPH-dependent carbonyl reductase 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C member 1
Description (eCommerce)
Carbonyl Reductase 1 / CBR1 is an NADPH-dependent reductase with broad substrate specificity. It catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. It also catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Carbonyl Reductase 1 / CBR1 can convert prostaglandin E2 to prostaglandin F2-alpha [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16152].
Description (Vector)
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.
Gene ID
873
Gene Name (eCommerce)
carbonyl reductase 1
Gene Name (Vector)
carbonyl reductase 1
Gene Symbol
CBR1
HGNC ID
HGNC:1548
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
834
ORF Size (bp)
834 bp
Protein Name (eCommerce)
Carbonyl reductase [NADPH] 1
RefSeq ID
NM_001757
RefSeq Synonyms
NM_001757, NM_001286789, BC015640, BC002511,
Research Areas
Cancer,Cardiology,Cardiovascular,Immunology,Metabolism/Metabolic Process
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,metabolism
Species
human
Target Sentence
Carbonyl Reductase 1 / CBR1 is an NADPH-dependent reductase with broad substrate specificity. It catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. It also catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Carbonyl Reductase 1 / CBR1 can convert prostaglandin E2 to prostaglandin F2-alpha [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16152].
UniGene ID
Hs.88778
UniProt ID (eCommerce)
P16152
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.