human CASP10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CASP10.
shADV-204111
Ad-h-CASP10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CASP10 (caspase 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALPS2; FLICE2; MCH4
Description (Vector)
CASP10 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
843
Gene Name (Vector)
caspase 10
Gene Symbol
CASP10
HGNC ID
HGNC:1500
ORF Size (aa)
1569
ORF Size (bp)
1569 bp
RefSeq ID
NM_001230
RefSeq Synonyms
NM_032977, NM_032976, NM_032974, NM_001306083, NM_001230, NM_001206542, NM_001206524, BC042844,
Species
human
UniGene ID
Hs.5353
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.