human C2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human C2.
shADV-203152
Ad-h-C2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human C2 (complement C2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARMD14; CO2
Description (Vector)
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Gene ID
717
Gene Name (Vector)
complement C2
Gene Symbol
C2
HGNC ID
HGNC:1248
ORF Size (aa)
2259
ORF Size (bp)
2259 bp
RefSeq ID
NM_000063
RefSeq Synonyms
NM_001282459, NM_001282458, NM_001282457, NM_001178063, NM_001145903, NM_000063, BC043484,
Species
human
UniGene ID
Hs.408903
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.