human KDM4A Over-expression AAV

Name 
AAV-h-KDM4A
Cat No 
AAV-212841
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KDM4A.

AAV-212841
AAV-h-KDM4A

Ready-to-use AAV expressing Human KDM4A (lysine demethylase 4A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
JHDM3A; jmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; lysine-specific demethylase 4A; TDRD14A; tudor domain containing 14A
Description (eCommerce)
JMJD2A is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2A is a trimethylation-specific demethylase and functions as a transcriptional repressor. JMJD2A interacts with pRb and class one histone deacetylases to mediate repression of E2F-regulated promoters.
Description (Vector)
KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Gene ID
9682
Gene Name (eCommerce)
lysine demethylase 4A
Gene Name (Vector)
lysine demethylase 4A
Gene Symbol
KDM4A
HGNC ID
HGNC:22978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3195
ORF Size (bp)
3195 bp
Protein Name (eCommerce)
Lysine-specific demethylase 4A
RefSeq ID
NM_014663
RefSeq Synonyms
NM_014663, BC002558,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation,genetics,infectious_disease,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
JMJD2A is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2A is a trimethylation-specific demethylase and functions as a transcriptional repressor. JMJD2A interacts with pRb and class one histone deacetylases to mediate repression of E2F-regulated promoters.
UniGene ID
Hs.155983
UniProt ID (eCommerce)
O75164

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.