human C10ORF119 shRNA silencing Adenovirus

Name 
Ad-h-C10ORF119-shRNA
Cat No 
shADV-202392
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MCMBP.

shADV-202392
Ad-h-C10ORF119-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MCMBP (minichromosome maintenance complex binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C10orf119; MCM-binding protein; MCM-BP; mini-chromosome maintenance complex-binding protein
Description (eCommerce)
MCM-binding protein is an associated component of the MCM (mini-chromosome maintenance) complex that acts as a regulator of DNA replication. MCM-BP binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. MCM-BP is required for sister chromatid cohesion [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BTE3].
Description (Vector)
MCMBP encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
79892
Gene Name (eCommerce)
minichromosome maintenance complex binding protein
Gene Name (Vector)
minichromosome maintenance complex binding protein
Gene Symbol
MCMBP
HGNC ID
HGNC:25782
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1923
ORF Size (bp)
1923 bp
Protein Name (eCommerce)
Mini-chromosome maintenance complex-binding protein
RefSeq ID
NM_024834
RefSeq Synonyms
NM_024834, NM_001256379, NM_001256378, BC007219, BC004183,
Research Areas
Cell Cycle,Cell Division,DNA Replication,Replication
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
MCM-binding protein is an associated component of the MCM (mini-chromosome maintenance) complex that acts as a regulator of DNA replication. MCM-BP binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. MCM-BP is required for sister chromatid cohesion [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BTE3].
UniGene ID
Hs.124246
UniProt ID (eCommerce)
Q9BTE3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.