human BTRC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BTRC.
shADV-202354
Ad-h-BTRC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Description (Vector)
BTRC encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
Gene ID
8945
Gene Name (Vector)
beta-transducin repeat containing E3 ubiquitin protein ligase
Gene Symbol
BTRC
HGNC ID
HGNC:1144
ORF Size (aa)
1818
ORF Size (bp)
1818 bp
RefSeq ID
NM_003939
RefSeq Synonyms
NM_033637, NM_003939, NM_001256856, BC027994,
Species
human
UniGene ID
Hs.643802
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.