human BCL6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BCL6.
shADV-202055
Ad-h-BCL6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BCL6 (B-cell CLL/lymphoma 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B-cell lymphoma 5 protein; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL5; BCL-5; BCL-6; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; ZBTB27; zinc finger and BTB domain-containing protein 27; zinc finger protein 51; zinc finger transcription factor BCL6S; ZNF51
Description (eCommerce)
Bcl6 is a zinc finger transcription factor and contains an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. Bcl6 can interact with a variety of POZ-containing proteins that function as transcription corepressors. Bcl6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL. [taken from NCBI Entrez Gene (Gene ID: 604)].
Description (Vector)
BCL6 is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Gene ID
604
Gene Name (eCommerce)
B cell CLL/lymphoma 6
Gene Name (Vector)
B-cell CLL/lymphoma 6
Gene Symbol
BCL6
HGNC ID
HGNC:1001
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
Protein Name (eCommerce)
B-cell lymphoma 6 protein
RefSeq ID
NM_001706
RefSeq Synonyms
NM_001706, NM_001134738, NM_001130845, BC150184, BC142705,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cell Cycle,Cytoskeleton,DNA Damage/Repair,FoxO Signaling,Immunology,Interleukin Signaling,Replication,Rho Signaling,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Bcl6 is a zinc finger transcription factor and contains an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. Bcl6 can interact with a variety of POZ-containing proteins that function as transcription corepressors. Bcl6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL. [taken from NCBI Entrez Gene (Gene ID: 604)].
UniGene ID
Hs.478588
UniProt ID (eCommerce)
P41182
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.