human BBS4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BBS4.
shADV-201999
Ad-h-BBS4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BBS4 (Bardet-Biedl syndrome 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
BBS4 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the protein's shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein 'BBSome' complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.
Gene ID
585
Gene Name (Vector)
Bardet-Biedl syndrome 4
Gene Symbol
BBS4
HGNC ID
HGNC:969
ORF Size (aa)
1560
ORF Size (bp)
1560 bp
RefSeq ID
NM_033028
RefSeq Synonyms
NM_033028, NM_001320665, NM_001252678, BC027624,
Species
human
UniGene ID
Hs.208681
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.