human BAK1 shRNA silencing Adenovirus

Name 
Ad-h-BAK1-shRNA
Cat No 
shADV-201953
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human BAK1.

shADV-201953
Ad-h-BAK1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BAK1 (BCL2 antagonist/killer 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
apoptosis regulator BAK; BAK; BAK-LIKE; bcl-2 homologous antagonist/killer; BCL2L7; bcl2-L-7; BCL2-like 7 protein; bcl-2-like protein 7; CDN1; pro-apoptotic protein BAK
Description (eCommerce)
Bcl-2 homologous antagonist/killer, the product of gene BAK1, belongs to the BCL2 protein family. This protein localizes to mitochondria, and functions to induce apoptosis. BAK1 interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress [taken from NCBI Entrez Gene (Gene ID: 578)].
Description (Vector)
BAK1 belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Gene ID
578
Gene Name (eCommerce)
BCL2 antagonist/killer 1
Gene Name (Vector)
BCL2 antagonist/killer 1
Gene Symbol
BAK1
HGNC ID
HGNC:949
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
636
ORF Size (bp)
636 bp
Protein Name (eCommerce)
Bcl-2 homologous antagonist/killer
RefSeq ID
NM_001188
RefSeq Synonyms
NM_001188, BC110337, BC004431,
Research Areas
Aging,Apoptosis,Brain Development,Breast Cancer,Cancer,Cardiovascular,Cell Cycle,DNA Damage/Repair,Gene Expression,Host-Virus Interactions,Immunology,Mitochondrion,Neurobiology,Neurodevelopment,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
Bcl-2 homologous antagonist/killer, the product of gene BAK1, belongs to the BCL2 protein family. This protein localizes to mitochondria, and functions to induce apoptosis. BAK1 interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress [taken from NCBI Entrez Gene (Gene ID: 578)].
UniGene ID
Hs.485139
UniProt ID (eCommerce)
Q16611

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.