human AXL shRNA silencing Adenovirus

Name 
Ad-h-AXL-shRNA
Cat No 
shADV-201858
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human AXL.

shADV-201858
Ad-h-AXL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AXL (AXL receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARK; AXL oncogene; AXL transforming sequence/gene; JTK11; Tyro7; tyrosine-protein kinase receptor UFO; UFO
Description (eCommerce)
Axl is a receptor tyrosine kinase (RTK) that binds the ligand Gas6 (growth-arrest specific gene). It is part of a sub-family of RTKs that includes Axl, SKY and MER. The Axl gene was first identified as a transforming cDNA isolated from patients with chronic myelogenous leukemia. Axl-Gas6 signaling is implicated in cellular responses such as cell survival, proliferation, migration, and adhesion, and it may be involved in cancer progression.
Description (Vector)
AXL is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
558
Gene Name (eCommerce)
AXL receptor tyrosine kinase
Gene Name (Vector)
AXL receptor tyrosine kinase
Gene Symbol
AXL
HGNC ID
HGNC:905
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2685
ORF Size (bp)
2685 bp
Protein Name (eCommerce)
Tyrosine-protein kinase receptor UFO
RefSeq ID
NM_021913
RefSeq Synonyms
NM_021913, NM_001699, NM_001278599, BC032229,
Research Areas
Apoptosis,Cancer,Cardiovascular,EGFR Signaling,IFN Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Axl is a receptor tyrosine kinase (RTK) that binds the ligand Gas6 (growth-arrest specific gene). It is part of a sub-family of RTKs that includes Axl, SKY and MER. The Axl gene was first identified as a transforming cDNA isolated from patients with chronic myelogenous leukemia. Axl-Gas6 signaling is implicated in cellular responses such as cell survival, proliferation, migration, and adhesion, and it may be involved in cancer progression.
UniGene ID
Hs.590970
UniProt ID (eCommerce)
P30530

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.