human AURKA shRNA silencing Adenovirus

Name 
Ad-h-AURKA-shRNA
Cat No 
shADV-201827
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human AURKA.

shADV-201827
Ad-h-AURKA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AURKA (aurora kinase A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AIK; ARK1; ARK-1; AURA; aurora 2; aurora kinase A; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora-related kinase 1; breast tumor-amplified kinase; BTAK; hARK1; PPP1R47; protein phosphatase 1, regulatory subunit 47; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
Description (eCommerce)
Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers.
Description (Vector)
AURKA is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
Gene ID
6790
Gene Name (eCommerce)
aurora kinase A
Gene Name (Vector)
aurora kinase A
Gene Symbol
AURKA
HGNC ID
HGNC:11393
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1212
ORF Size (bp)
1212 bp
Protein Name (eCommerce)
Aurora kinase A
RefSeq ID
NM_003600
RefSeq Synonyms
NM_198437, NM_198436, NM_198435, NM_198434, NM_198433, NM_003600, NM_001323305, NM_001323304, NM_001323303, BC027464, BC006423, BC002499, BC001280,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,EGFR Signaling,Kinase/Phosphatase,Meiosis,Phospho-specific,PLK1 Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction
Species
human
Target Sentence
Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers.
UniGene ID
Hs.250822
UniProt ID (eCommerce)
O14965

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.