human KCNQ3 Over-expression AAV

Name 
AAV-h-KCNQ3
Cat No 
AAV-212773
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KCNQ3.

AAV-212773
AAV-h-KCNQ3

Ready-to-use AAV expressing Human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BFNC2; EBN2; KV7.3
Description (Vector)
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found.
Gene ID
3786
Gene Name (Vector)
potassium voltage-gated channel subfamily Q member 3
Gene Symbol
KCNQ3
HGNC ID
HGNC:6297
ORF Size (aa)
2616
ORF Size (bp)
2616 bp
RefSeq ID
NM_004519
RefSeq Synonyms
NM_004519, NM_001204824, BC152755,
Species
human
UniGene ID
Hs.374023

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.