human ASXL2 shRNA silencing Adenovirus

Name 
Ad-h-ASXL2-shRNA
Cat No 
shADV-201595
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ASXL2.

shADV-201595
Ad-h-ASXL2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ASXL2 (additional sex combs like 2, transcriptional regulator). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
additional sex combs like 2, transcriptional regulator; additional sex combs-like protein 2; ASXH2; polycomb group protein ASXH2; putative Polycomb group protein ASXL2; SHAPNS
Description (eCommerce)
The gene that encodes Additional sex combs-like protein 2 (ASXL2) is a homolog of the drosophila additional sex combs (Asx) gene. Drosophila Asx is in a class of proteins known as ETP (enhancers of trithorax and polycomb). ETP proteins regulate polycomb-group (PcG) and trithorax-group (trxG) proteins which function to modify the methylation of histones and structure of chromatin. Mutations in ASXL1 are implicated in the development of myelodysplastic syndromes (MDS), a group of hematological diseases characterized by ineffective hematopoiesis and a predisposition to acute myeloid leukemia (AML).
Description (Vector)
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 (PubMed 12888926)).(supplied by OMIM, Sep 2009)
Gene ID
55252
Gene Name (eCommerce)
ASXL transcriptional regulator 2
Gene Name (Vector)
additional sex combs like 2, transcriptional regulator
Gene Symbol
ASXL2
HGNC ID
HGNC:23805
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
Protein Name (eCommerce)
Putative Polycomb group protein ASXL2
RefSeq ID
NM_018263
RefSeq Synonyms
NM_018263, BC042999,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
The gene that encodes Additional sex combs-like protein 2 (ASXL2) is a homolog of the drosophila additional sex combs (Asx) gene. Drosophila Asx is in a class of proteins known as ETP (enhancers of trithorax and polycomb). ETP proteins regulate polycomb-group (PcG) and trithorax-group (trxG) proteins which function to modify the methylation of histones and structure of chromatin. Mutations in ASXL1 are implicated in the development of myelodysplastic syndromes (MDS), a group of hematological diseases characterized by ineffective hematopoiesis and a predisposition to acute myeloid leukemia (AML).
UniGene ID
Hs.594386
UniProt ID (eCommerce)
Q76L83

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.