human ASXL1 shRNA silencing Adenovirus

Name 
Ad-h-ASXL1-shRNA
Cat No 
shADV-201593
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ASXL1.

shADV-201593
Ad-h-ASXL1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ASXL1 (additional sex combs like 1, transcriptional regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BOPS; MDS
Description (Vector)
ASXL1 is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Gene ID
171023
Gene Name (Vector)
additional sex combs like 1, transcriptional regulator
Gene Symbol
ASXL1
HGNC ID
HGNC:18318
ORF Size (aa)
4626
ORF Size (bp)
4626 bp
RefSeq ID
NM_015338
RefSeq Synonyms
NM_015338, NM_001164603, BC137280, BC137278,
Species
human
UniGene ID
Hs.374043

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.