human ARPC4 shRNA silencing Adenovirus

Name 
Ad-h-ARPC4-shRNA
Cat No 
shADV-201466
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ARPC4.

shADV-201466
Ad-h-ARPC4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARPC4 (actin related protein 2/3 complex subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4; ARC20; arp2/3 complex 20 kDa subunit; arp2/3 protein complex subunit p20; P20-ARC
Description (eCommerce)
Actin-related protein 2/3 complex subunit 4 (ARPC4) functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC4 seems to contact the mother actin filament [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P59998].
Description (Vector)
ARPC4 encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. ARPC4 encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein.
Gene ID
10093
Gene Name (eCommerce)
actin related protein 2/3 complex subunit 4
Gene Name (Vector)
actin related protein 2/3 complex subunit 4
Gene Symbol
ARPC4
HGNC ID
HGNC:707
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
504
ORF Size (bp)
504 bp
Protein Name (eCommerce)
Actin-related protein 2/3 complex subunit 4
RefSeq ID
NM_005718
RefSeq Synonyms
NM_005718, NM_001198780, NM_001024960, NM_001024959, BC152790, BC065423,
Research Areas
Cytoskeleton,Immunology,Innate Immunity,PDGF Signaling,RAC1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Actin-related protein 2/3 complex subunit 4 (ARPC4) functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC4 seems to contact the mother actin filament [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P59998].
UniGene ID
Hs.323342
UniProt ID (eCommerce)
P59998

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.