human APBB1 shRNA silencing Adenovirus

Name
Ad-h-APBB1-shRNA

Cat No
shADV-201120

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human APBB1.

shADV-201120

Ad-h-APBB1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human APBB1 (amyloid beta precursor protein binding family B member 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

FE65; MGC:9072; RIR

Description (Vector)

APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

322

Gene Name (Vector)

amyloid beta precursor protein binding family B member 1

Gene Symbol

APBB1

HGNC ID

HGNC:581

ORF Size (aa)

2127

ORF Size (bp)

2127 bp

RefSeq ID

NM_001164

RefSeq Synonyms

NM_145689, NM_001257326, NM_001257325, NM_001257323, NM_001257321, NM_001257320, NM_001257319, NM_001164, BC010854,

Species

human

UniGene ID

Hs.372840

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.