human ANAPC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ANAPC1.
shADV-200894
Ad-h-ANAPC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ANAPC1 (anaphase promoting complex subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
anaphase-promoting complex 1 (meiotic checkpoint regulator); anaphase-promoting complex subunit 1; APC1; cyclosome subunit 1; MCPR; mitotic checkpoint regulator; testis-specific gene 24 protein; TSG24
Description (eCommerce)
Anaphase-promoting complex subunit 1(APC1) is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase and is responsible for the ubiquitination of securin and cyclin B and prompts the onset of anaphase and the exit from mitosis. The APC complex is composed of at least 11 APC components. APC1 is the largest of these subunits.
Description (Vector)
ANAPC1 encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation.
Gene ID
64682
Gene Name (eCommerce)
anaphase promoting complex subunit 1
Gene Name (Vector)
anaphase promoting complex subunit 1
Gene Symbol
ANAPC1
HGNC ID
HGNC:19988
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5835
ORF Size (bp)
5835 bp
Protein Name (eCommerce)
Anaphase-promoting complex subunit 1
RefSeq ID
NM_022662
RefSeq Synonyms
NM_022662, BC104904, BC104902,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Host-Virus Interactions,Immunology,Meiosis,Signal Transduction,TGF-beta Signaling,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Anaphase-promoting complex subunit 1(APC1) is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase and is responsible for the ubiquitination of securin and cyclin B and prompts the onset of anaphase and the exit from mitosis. The APC complex is composed of at least 11 APC components. APC1 is the largest of these subunits.
UniGene ID
Hs.436527
UniProt ID (eCommerce)
Q9H1A4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.