human ALDH1A1 shRNA silencing Adenovirus

Name 
Ad-h-ALDH1A1-shRNA
Cat No 
shADV-200725
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ALDH1A1.

shADV-200725
Ad-h-ALDH1A1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
acetaldehyde dehydrogenase 1; ALDC; aldehyde dehydrogenase 1, soluble; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; ALDH1; ALDH11; ALDH-E1; ALHDII; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; HEL12; HEL-9; HEL-S-53e; PUMB1; RALDH 1; RALDH1; retinal dehydrogenase 1; retinaldehyde dehydrogenase 1
Description (eCommerce)
ALDH1A1 is a liver cytosolic form of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism. ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism. [taken from NCBI Entrez Gene (Gene ID: 216)].
Description (Vector)
ALDH1A1 belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
Gene ID
216
Gene Name (eCommerce)
aldehyde dehydrogenase 1 family member A1
Gene Name (Vector)
aldehyde dehydrogenase 1 family member A1
Gene Symbol
ALDH1A1
HGNC ID
HGNC:402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1506
ORF Size (bp)
1506 bp
Protein Name (eCommerce)
Retinal dehydrogenase 1
RefSeq ID
NM_000689
RefSeq Synonyms
NM_000689, BC001505,
Research Areas
Cancer,Metabolism/Metabolic Process
Research Areas (Faceted)
cancer,cell_biology,metabolism
Species
human
Target Sentence
ALDH1A1 is a liver cytosolic form of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism. ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism. [taken from NCBI Entrez Gene (Gene ID: 216)].
UniGene ID
Hs.76392
UniProt ID (eCommerce)
P00352

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.