human AKAP5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AKAP5.
shADV-200660
Ad-h-AKAP5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AKAP5 (A-kinase anchoring protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AKAP75; AKAP79; H21
Description (Vector)
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
Gene ID
9495
Gene Name (Vector)
A-kinase anchoring protein 5
Gene Symbol
AKAP5
HGNC ID
HGNC:375
ORF Size (aa)
1284
ORF Size (bp)
1284 bp
RefSeq ID
NM_004857
RefSeq Synonyms
NM_004857, BC131516,
Species
human
UniGene ID
Hs.656683
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.