human AHCY shRNA silencing Adenovirus

Name
Ad-h-AHCY-shRNA

Cat No
shADV-200595

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human AHCY.

shADV-200595

Ad-h-AHCY-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AHCY (adenosylhomocysteinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

adoHcyase; SAHH

Description (Vector)

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

191

Gene Name (Vector)

adenosylhomocysteinase

Gene Symbol

AHCY

HGNC ID

HGNC:343

ORF Size (aa)

921

RefSeq ID

NM_000687

RefSeq Synonyms

NM_001322086, NM_001322085, NM_001322084, NM_001161766, NM_000687, BC114924, BC011606, BC010018,

Species

human

UniGene ID

Hs.388004

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.