human AGT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AGT.
shADV-200581
Ad-h-AGT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AGT (angiotensinogen). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ANHU; SERPINA8
Description (Vector)
AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Gene ID
183
Gene Name (Vector)
angiotensinogen
Gene Symbol
AGT
HGNC ID
HGNC:333
ORF Size (aa)
1458
ORF Size (bp)
1458 bp
RefSeq ID
NM_000029
RefSeq Synonyms
NM_000029, BC011519,
Species
human
UniGene ID
Hs.19383
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.