human ADAMTS4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ADAMTS4.
shADV-200389
Ad-h-ADAMTS4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADAMTS-2; ADAMTS-4; ADMP-1
Description (Vector)
ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Gene ID
9507
Gene Name (Vector)
ADAM metallopeptidase with thrombospondin type 1 motif 4
Gene Symbol
ADAMTS4
HGNC ID
HGNC:220
ORF Size (aa)
2514
ORF Size (bp)
2514 bp
RefSeq ID
NM_005099
RefSeq Synonyms
NM_005099, NM_001320336, BC063293, BC030812,
Species
human
UniGene ID
Hs.211604
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.