human ACVR2B shRNA silencing Adenovirus

Name
Ad-h-ACVR2B-shRNA

Cat No
shADV-200331

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ACVR2B.

shADV-200331

Ad-h-ACVR2B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ACVR2B (activin A receptor, type IIB). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ActR-IIB; ACTRIIB; MGC116908;

Description (Vector)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Gene ID

Gene Name (Vector)

activin A receptor, type IIB

Gene Symbol

ACVR2B

ORF Size (aa)

912

ORF Size (bp)

912 bp

RefSeq ID

NM_001106

RefSeq Synonyms

NM_001106, BC099642, BC096245, BC096244, BC096243,

Species

human

UniGene ID

Hs.174273

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.