human ACVR2A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ACVR2A.
shADV-200326
Ad-h-ACVR2A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ACVR2A (activin A receptor type 2A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACTRII; ACVR2
Description (Vector)
ACVR2A encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Gene ID
92
Gene Name (Vector)
activin A receptor type 2A
Gene Symbol
ACVR2A
HGNC ID
HGNC:173
ORF Size (aa)
1542
ORF Size (bp)
1542 bp
RefSeq ID
NM_001616
RefSeq Synonyms
NM_001616, NM_001278580, NM_001278579, BC069707, BC067418, BC067417,
Species
human
UniGene ID
Hs.470174
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.